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apalutamide will lower the extent or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medication which might be CYP2C19 substrates may result in lower exposure to these medications.butabarbital will decrease the level or impact of diaze